Harriers made a bright start, going close inside the first minute when Foster's 10-yard effort fell straight to keeper Marshall.
The visitors exploited Cambridge's off-side trap on several occasions but their delivery of crosses into the box was poor.
Harriers picked-up two booking with Flynn cautioned on 21 minutes after catching Nacca in the face with a flying boot. Sean Flynn
Eight minutes later Smith was also yellow carded for a lunging foul on midfielder Gutteridge.
Harriers, who started with a 4-4-1-1 formation with Bishop upfront and Melligan pushing up in a free roll, were grateful to right-back Smith for a good block on Kitson's shot in the 34th minute.
Earlier, the ball fell for home defender Iriekpen in the box but he poked a weak effort straight at the grateful Digby.
The match was watched by a crowd of 3,705, including 259 away fans.
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