Harriers will be missing 18 goal top scorer Bo Henriksen who tweaked a hamstring in training yesterday.
Fellow frontman Drew Broughton is on the bench, meaning a first start for Ian Foster since November 16 against Rushden.
Boss Britton is likely to change from his regular 3-5-2 formation with Andy Bishop possibly on his own upfront.
Cambridge are unchanged from their midweek 2-1 win at Darlington.
Cambridge: Marshall; Goodhind, Iriekpen, Angus, Murray; Guttridge, Nacca, Fleming, Newey; Kitson, Riza.
Subs: Wanless, Youngs, Chillingworth, Brennon, Theobald.
Harriers: Digby; Smith, Morgan, Scott, Hinton, Shilton; Melligan, Flynn, Williams, Foster; Bishop.
Subs: Brock, Stamps, Parrish Broughton, Ayres.
Referee: R Pearson, Durham.
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